Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai, China.
Diabetes Care. 2013 Sep;36(9):2810-4. doi: 10.2337/dc12-1766. Epub 2013 Apr 29.
Fibroblast growth factor 19 (FGF19), a hormone secreted from the small intestine, has recently been shown to stimulate glycogen synthesis and inhibit gluconeogenesis through insulin-independent pathways. This study investigated the change of FGF19 in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM) and explored the association of serum FGF19 levels with parameters of glucose metabolism in Chinese subjects.
Fasting serum FGF19 levels were determined by ELISA in 81 normal glucose tolerance (NGT), 91 impaired fasting glucose (IFG), 93 impaired glucose tolerance (IGT), and 104 newly diagnosed T2DM subjects, and their association with parameters of glucose metabolism was studied. An ordinal logistic regression analysis was performed in subjects with NGT, IFG, and T2DM. Serum FGF19 levels at 2 h after a 75-g oral glucose tolerance test in the different glucose tolerance categories were studied in a subgroup.
Fasting serum FGF19 levels in subjects with IFG (210 pg/mL [142-327]) (median [interquartile range]) and T2DM (196 pg/mL [137-280]) were significantly lower than those in NGT subjects (289 pg/mL [224-393]) (both P < 0.001). However, no significant difference in fasting FGF19 levels was observed between IGT (246 pg/mL [138-379]) and NGT subjects. Fasting serum FGF19 levels were negatively associated with fasting plasma glucose and independently associated with the deterioration of glucometabolic status from NGT to IFG and T2DM.
Fasting serum FGF19 levels were decreased in Chinese subjects with IFG and inversely associated with fasting glucose levels.
成纤维细胞生长因子 19（FGF19）是一种从小肠分泌的激素，最近研究表明它通过胰岛素非依赖途径刺激糖原合成并抑制糖异生。本研究旨在探讨糖尿病前期和新诊断的 2 型糖尿病（T2DM）患者中 FGF19 的变化，并探讨血清 FGF19 水平与中国人群糖代谢参数的关系。
采用酶联免疫吸附试验（ELISA）法检测 81 例正常糖耐量（NGT）、91 例空腹血糖受损（IFG）、93 例糖耐量受损（IGT）和 104 例新诊断的 T2DM 患者空腹血清 FGF19 水平，并研究其与糖代谢参数的关系。对 NGT、IFG 和 T2DM 患者进行有序逻辑回归分析。在不同糖耐量组中，研究了口服葡萄糖耐量试验 2 小时后血清 FGF19 水平。
IFG 组（210pg/ml [142-327]）和 T2DM 组（196pg/ml [137-280]）空腹血清 FGF19 水平明显低于 NGT 组（289pg/ml [224-393]）（均 P <0.001）。然而，IGT 组（246pg/ml [138-379]）空腹血清 FGF19 水平与 NGT 组无显著差异。空腹血清 FGF19 水平与空腹血糖呈负相关，与 NGT 向 IFG 和 T2DM 的糖代谢状态恶化独立相关。
中国 IFG 患者空腹血清 FGF19 水平降低，与空腹血糖水平呈负相关。
