血清成纤维细胞生长因子19水平降低是1型糖尿病的一个危险因素。
Decreased serum fibroblast growth factor 19 level is a risk factor for type 1 diabetes.
作者信息
Hu Jingyi, Tang Yingxin, Liu Hui, Li Yanhua, Li Xia, Huang Gan, Xiao Yang, Zhou Zhiguang
机构信息
Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Metabolic Diseases, Changsha, China.
出版信息
Ann Transl Med. 2021 Mar;9(5):376. doi: 10.21037/atm-20-5203.
BACKGROUND
Increasing evidence suggests that fibroblast growth factor 19 (FGF19) is a regulator of glucose metabolism and may provide a new therapeutic target for type 1 diabetes (T1D). However, the clinical relevance of FGF19 in T1D remains unclear. In this study, we examined the relationship between the serum FGF19 concentration and T1D.
METHODS
This study included 81 newly diagnosed T1D patients and 80 sex- and age-matched healthy controls. The correlation between the FGF19 concentration and clinical characteristics of T1D patients and healthy controls was investigated. Logistic regression analysis was performed to determine whether levels of FGF19 were independently associated with T1D.
RESULTS
The fasting serum FGF19 levels in the T1D group were significantly lower than those in the control group [159.9 (100.0-272.7) 205.0 (126.9-307.9) pg/mL, P=0.008]. In all subjects, serum FGF19 levels were negatively correlated with fasting blood glucose (FBG) (r=-0.192, P=0.015). In the control group, serum FGF19 levels were positively correlated with total cholesterol (TC) (r=0.338, P=0.002) and low-density lipoprotein cholesterol (LDL-c) (r=0.300, P=0.007). In addition to sex and body mass index (BMI), FGF19 was an independent impact factor for T1D [odds ratio (OR) =0.541, P=0.023; adjusted for sex, age, BMI, presence of hypertension, and presence of dyslipidemia].
CONCLUSIONS
Low serum FGF19 level is associated with T1D, which could serve as a risk factor for T1D.
背景
越来越多的证据表明，成纤维细胞生长因子19（FGF19）是葡萄糖代谢的调节因子，可能为1型糖尿病（T1D）提供新的治疗靶点。然而，FGF19在T1D中的临床相关性仍不清楚。在本研究中，我们检测了血清FGF19浓度与T1D之间的关系。
方法
本研究纳入81例新诊断的T1D患者和80例年龄、性别匹配的健康对照。研究FGF19浓度与T1D患者及健康对照临床特征之间的相关性。进行逻辑回归分析以确定FGF19水平是否与T1D独立相关。
结果
T1D组空腹血清FGF19水平显著低于对照组[159.9（100.0 - 272.7）对205.0（126.9 - 307.9）pg/mL，P = 0.008]。在所有受试者中，血清FGF19水平与空腹血糖（FBG）呈负相关（r = -0.192，P = = 0.015）。在对照组中，血清FGF19水平与总胆固醇（TC）呈正相关（r = 0.338，P = 0.002）及低密度脂蛋白胆固醇（LDL - c）呈正相关（r = 0.300，P = 0.007）。除性别和体重指数（BMI）外，FGF19是T1D的独立影响因素[比值比（OR）= 0.541，P = 0.023；校正性别、年龄、BMI、高血压及血脂异常情况后]。
结论
血清FGF19水平低与T1D相关联，其可作为T1D的一个危险因素。
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