正常女性和不孕患者子宫内膜中的催产素结合位点
Endometrial oxytocin binding sites in normal women and in subfertile patients.
作者信息
Baker P N, Peat M L, Symonds E M, Maynard P V
机构信息
Department of Obstetrics and Gynaecology, University Hospital, Queen's Medical Centre, Nottingham, UK.
出版信息
Postgrad Med J. 1990 Mar;66(773):195-9. doi: 10.1136/pgmj.66.773.195.
Specific binding of oxytocin to high affinity sites in endometrial membrane preparations has previously been shown in sheep. Endometrial tissue preparations from 27 'normal' women of proven fertility were incubated with tritiated oxytocin and the existence of significant binding sites in human endometrium was shown. Furthermore, the level of binding sites underwent a cyclical variation with the highest concentration of binding at midcycle. A cyclical pattern of binding site concentration not unlike that found in the normal women was shown in 19 subfertile patients taking clomiphene. However, in 20 subfertile patients not taking clomiphene, no cyclical pattern emerged with significantly lower levels of binding sites in the mid-portion of the cycle (P less than 0.02) and significantly higher levels in the mid-late luteal phase (P less than 0.01), as compared to the normal women. In the mid-portion of the cycle levels were significantly lower in the subfertile patients not taking clomiphene (P less than 0.03) as compared to those taking clomiphene. No significant differences were shown between the normal women and those patients taking clomiphene.
先前已证明，在绵羊的子宫内膜膜制剂中，催产素可与高亲和力位点特异性结合。将来自27名已证实具有生育能力的“正常”女性的子宫内膜组织制剂与氚标记的催产素一起孵育，结果表明人子宫内膜中存在显著的结合位点。此外，结合位点的水平呈现周期性变化，在月经周期中期结合浓度最高。19名服用克罗米芬的不育患者也表现出与正常女性相似的结合位点浓度周期性模式。然而，在20名未服用克罗米芬的不育患者中，未出现周期性模式，与正常女性相比，在月经周期中期结合位点水平显著降低（P<0.02），而在黄体中期至后期显著升高（P<0.01）。与服用克罗米芬的不育患者相比，未服用克罗米芬的不育患者在月经周期中期的水平显著降低（P<0.03）。正常女性与服用克罗米芬的患者之间未显示出显著差异。
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