Levy C, Robel P, Gautray J P, De Brux J, Verma U, Descomps B, Baulieu E E
Am J Obstet Gynecol. 1980 Mar 1;136(5):646-51. doi: 10.1016/0002-9378(80)91018-2.
Estradiol and progesterone receptor sites (empty or filled with endogenous hormone)have been measured in the cytoplasm and nuclei of human endometrium. Receptor changes have been observed throughout the normal menstrual cycle. During the preovulatory phase the cytoplasmic estradiol receptor sites do not change while the nuclear receptor sites more than double. Cytoplasmic estradiol receptor sites decrease very early in the secretory phase, whereas the decrease in nuclear sites occurs later. Cytoplasmic progesterone receptor sites more than double during the preovulatory phase and show a large decrease immediately after ovulation, when the concentration of nuclear receptor is at its highest. Thus the total cellular concentrations of both estradiol and progesterone receptors are lowest in the late secretory phase. It was found that they are positively correlated with the concentration of plasma estradiol only during the proliferative phase. The concentration of cytoplasmic progesterone receptor is negatively correlated with 17 beta-hydroxysteroid oxidoreductase activity during the secretory phase. In anovulatory cycles the concentrations of estradiol and progesterone receptors are high, similar to those of the late proliferative phase. "luteal insufficiency" is characterized by a very low concentration of estradiol receptor. Early pregnancy endometrium (8 to 10 weeks' gestation) is characterized by a large concentration of progesterone receptor, exceeding those of any period of the menstrual cycle.
已对人子宫内膜细胞质和细胞核中的雌二醇及孕酮受体位点（空的或结合内源性激素的）进行了测定。在整个正常月经周期中均观察到受体变化。在排卵前期，细胞质中的雌二醇受体位点不变，而细胞核中的受体位点增加一倍多。细胞质中的雌二醇受体位点在分泌期早期就开始减少，而细胞核中的受体位点减少则出现得较晚。细胞质中的孕酮受体位点在排卵前期增加一倍多，并在排卵后立即大幅减少，此时细胞核受体浓度处于最高水平。因此，雌二醇和孕酮受体的总细胞浓度在分泌晚期最低。发现仅在增殖期它们与血浆雌二醇浓度呈正相关。在分泌期，细胞质孕酮受体浓度与17β-羟类固醇氧化还原酶活性呈负相关。在无排卵周期中，雌二醇和孕酮受体浓度较高，类似于增殖晚期。“黄体功能不全”的特征是雌二醇受体浓度非常低。妊娠早期子宫内膜（妊娠8至10周）的特征是孕酮受体浓度很高，超过月经周期任何时期。
