Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
Small. 2013 Jun 24;9(12):2034-44. doi: 10.1002/smll.201202485. Epub 2013 Apr 30.
Nanocarriers are a new type of nonviral gene carriers, many of which have demonstrated a broad range of pharmacological and biological properties, such as being biodegradable in the body, stimulus-responsive towards the surrounding environment, and an ability to specifically targeting certain disease sites. By summarizing some main types of nanocarriers, this Concept considers the current status and possible future directions of the potential clinical applications of multifunctional nanocarriers, with primary attention on the combination of such properties as biodegradability, targetability, transfection ability, and stimuli sensitivity.
纳米载体是一种新型的非病毒基因载体，其中许多已表现出广泛的药理学和生物学特性，例如在体内可生物降解、对周围环境具有刺激响应性、以及能够特异性靶向某些疾病部位。通过总结一些主要类型的纳米载体，本综述考虑了多功能纳米载体潜在临床应用的现状和可能的未来方向，主要关注生物降解性、靶向性、转染能力和刺激敏感性等特性的结合。
