真核生物膜细胞色素 P450 的结构多样性。
Structural diversity of eukaryotic membrane cytochrome p450s.
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Biol Chem. 2013 Jun 14;288(24):17082-90. doi: 10.1074/jbc.R113.452805. Epub 2013 Apr 30.
Abstract
X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance.
摘要
X 射线晶体结构可用于 29 种真核微粒体、叶绿体或线粒体细胞色素 P450，包括两种非单加氧酶 P450。这些结构为理解它们独特的催化活性所依据的结构-功能关系提供了基础。此外，还对个别 P450 的结构可塑性进行了描述，这有助于理解介导药物清除的 P450 中底物的结合。
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