Foin Nicolas, Mari Jean Martial, Nijjer Sukhjinder, Sen Sayan, Petraco Ricardo, Ghione Matteo, Di Mario Carlo, Davies Justin E, Girard Michaël J A
International Centre for Circulatory Health, Imperial College London, W2 1LA London, UK.
Cardiovasc Revasc Med. 2013 May-Jun;14(3):139-43. doi: 10.1016/j.carrev.2013.03.007. Epub 2013 Apr 28.
To allow an accurate diagnosis of coronary artery diseases by enhancing optical coherence tomography (OCT) images of atheromatous plaques using a novel automated attenuation compensation technique.
One of the major drawbacks of coronary OCT imaging is the rapid attenuation of the OCT signal, limiting penetration in tissue to only few millimetres. Visualisation of deeper anatomy is however critical for accurate assessment of plaque burden in-vivo.
A compensation algorithm, previously developed to correct for light attenuation in soft tissues and to enhance contrast in ophthalmic OCT images, was applied to intracoronary plaque imaging using spectral-domain OCT.
Application of the compensation algorithm significantly increased tissue contrast in the vessel wall and atherosclerotic plaque boundaries. Contrast enhancement allows a better differentiation of plaque morphology, which is particularly important for the identification of lipid rich fibro atheromatous plaques and to guide decision on treatment strategy.
The analysis of arterial vessel structure clinically captured with OCT is improved when used in conjunction with automated attenuation compensation. This approach may improve the OCT-based interpretation of coronary plaque morphology in clinical practice.
通过使用一种新型自动衰减补偿技术增强动脉粥样硬化斑块的光学相干断层扫描（OCT）图像，实现对冠状动脉疾病的准确诊断。
冠状动脉OCT成像的主要缺点之一是OCT信号的快速衰减，这限制了其在组织中的穿透深度仅为几毫米。然而，更深层解剖结构的可视化对于体内斑块负荷的准确评估至关重要。
一种先前开发用于校正软组织中光衰减并增强眼科OCT图像对比度的补偿算法，被应用于使用光谱域OCT的冠状动脉内斑块成像。
补偿算法的应用显著增加了血管壁和动脉粥样硬化斑块边界处的组织对比度。对比度增强有助于更好地区分斑块形态，这对于识别富含脂质的纤维粥样斑块以及指导治疗策略的决策尤为重要。
当与自动衰减补偿结合使用时，临床上用OCT捕获的动脉血管结构分析得到改善。这种方法可能会改善临床实践中基于OCT的冠状动脉斑块形态解释。
