Division of Epidemiology, Department of Population Health, New York University School of Medicine, 650 First Ave, New York, NY 10016, USA.
Prev Med. 2013 Jul;57(1):60-4. doi: 10.1016/j.ypmed.2013.04.014. Epub 2013 Apr 28.
Obesity is a risk factor for cardiovascular disease (CVD) mortality, but the association between obesity and specific causes of CVD mortality is still under investigation.
We prospectively examined body-mass index (BMI) in relation to CVD-specific causes of death in approximately 86,000 US men and women in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, followed for up to 13 years. BMI was calculated from self-reported weight and height at baseline. Hazard ratios (HRs) were calculated overall and stratified by sex, smoking status, and educational level.
Overweight non-obese participants (BMI: 25.0-29.9) were not at excess risk for CVD mortality (HR and CIs are 1.02 [0.92-1.13]), compared to participants of normal BMI (18.5-24.9). Excess CVD mortality was observed for participants of BMI 30.0-34.9 (HR and CIs: 1.29 [1.13-1.48]), BMI 35.0-39.9 (HR and CIs: 1.87 [1.51-2.32]) and BMI 40.0+ (HR and CIs: 2.21 [1.57-3.21]) (p<0.001 for trend). BMI was unrelated to mortality due to stroke. The observed association of BMI with CVD was independent of gender, smoking status and educational level.
Obesity is associated with increased mortality due to CVD.
肥胖是心血管疾病（CVD）死亡率的一个危险因素，但肥胖与 CVD 特定死因之间的关系仍在研究之中。
我们前瞻性地研究了大约 86000 名美国男性和女性在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验（Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial，PLCO）中与 CVD 特定死因相关的体重指数（BMI），随访时间长达 13 年。BMI 是根据基线时的自我报告体重和身高计算得出的。计算了总体和按性别、吸烟状况和教育程度分层的风险比（HR）。
超重非肥胖参与者（BMI：25.0-29.9）与正常 BMI 参与者（18.5-24.9）相比，CVD 死亡率没有过高的风险（HR 和 95%CI 为 1.02[0.92-1.13]）。对于 BMI 为 30.0-34.9（HR 和 95%CI 为 1.29[1.13-1.48]）、BMI 为 35.0-39.9（HR 和 95%CI 为 1.87[1.51-2.32]）和 BMI 为 40.0+（HR 和 95%CI 为 2.21[1.57-3.21]）的参与者，观察到 CVD 死亡率过高（p<0.001 趋势）。BMI 与中风导致的死亡率无关。观察到的 BMI 与 CVD 的关联独立于性别、吸烟状况和教育程度。
肥胖与 CVD 导致的死亡率增加有关。
