The Healthy Brain Ageing Clinic, School of Psychology, The University of Sydney, Camperdown, NSW, Australia.
Woolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Central Clinical School, Glebe, NSW, Australia.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Jan;27(1):140-151. doi: 10.1080/13825585.2019.1597009. Epub 2019 Apr 18.
Cardiovascular disease in older people is often linked with cognitive impairment, particularly in domains of executive function and processing speed. Our aims examined whether carotid-femoral pulse wave velocity (PWV) related to subtle changes of executive function and processing speed. Fifty-six individuals with subjective mood and/or cognitive concerns underwent PWV and neuropsychological assessments of processing speed (Trail Making Test Part A) and executive functioning (Delis Kaplan Executive Function System Stroop Task; Trail Making Test Part B, TMT-B). Individuals with high PWV (≥12.0m/s) had poorer performance on TMT-B, compared to low PWV (<12.0m/s), and a moderate negative correlation (r = -0.38, p = .004) between PWV and TMT-B performance. Our results confirm that in older adults at-risk for cognitive decline, early markers of CVD are associated with subtle decrements in rapid set-shifting (executive function), supporting efforts towards early detection of CVD as a secondary prevention strategy for older individuals with cognitive decline.
老年人的心血管疾病通常与认知障碍有关，特别是在执行功能和处理速度方面。我们的目的是研究颈动脉-股动脉脉搏波速度（PWV）是否与执行功能和处理速度的细微变化有关。56 名有主观情绪和/或认知问题的个体接受了 PWV 和神经心理学评估，包括处理速度（连线测试 A）和执行功能（Delis Kaplan 执行功能系统斯特鲁普任务；连线测试 B，TMT-B）。与低 PWV（<12.0m/s）相比，高 PWV（≥12.0m/s）个体在 TMT-B 上的表现更差，并且 PWV 与 TMT-B 表现之间存在中度负相关（r=-0.38，p=0.004）。我们的结果证实，在有认知能力下降风险的老年人中，心血管疾病的早期标志物与快速转换（执行功能）的细微下降有关，这支持了将心血管疾病的早期检测作为认知能力下降的老年个体的二级预防策略。
