Department of Radiology, University of British Columbia (UBC), 2775 Laurel St., Vancouver V5Z 1M9, Canada; Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver V6T 1Z3, Canada.
Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver V6T 1Z3, Canada; Department of Physical Therapy, Aging, Mobility, and Cognitive Health Lab, UBC, 109-828 West 10th Ave., Vancouver V5Z 1M9, Canada; Centre for Hip Health and Mobility, Robert H.N. Ho Research Centre, 2635 Laurel St., Vancouver V5Z 1M9, Canada.
J Stroke Cerebrovasc Dis. 2022 Jan;31(1):106175. doi: 10.1016/j.jstrokecerebrovasdis.2021.106175. Epub 2021 Oct 26.
To examine potential sex differences in the relationship between arterial stiffness and global cognitive function and executive functions.
Baseline data from 80 older adults were included from two randomized controlled trials (NCT02669394 and NCT02737878). Arterial stiffness was measured by carotid-femoral pulse wave velocity (cf-PWV). Cognitive function assessment included global cognition (Mini-Mental State Examination [MMSE]) and executive functions (set shifting [Trail Making Test Part B minus A], inhibition [Stroop Test], and working memory [Verbal Digit Span Backwards Test]). Separate statistical models were constructed to assess the effect of cf-PWV on each cognitive outcome for females and males. Each statistical model controlled for Framingham cardiovascular disease risk score and education.
Higher cf-PWV was associated with impaired MMSE performance in males (β = -0.48; p = 0.018), but not females (p ≥ 0.389). For executive processes, higher cf-PWV was associated with impaired Trail Making Test Part B minus A (β = 0.56; p = 0.005) and Stroop Test (β = 0.59; p = 0.004) in males, but not in females (ps ≥ 0.108). cf-PWV was not significantly associated with Verbal Digit Span Forward minus Backward Test in males or females (ps ≥ 0.108).
Arterial stiffness is more strongly associated with cognitive impairment in males than females. These results further elucidate the interplay between vascular health and cognitive function by providing support for sex-specific mechanisms.
探讨动脉僵硬度与整体认知功能和执行功能之间的关系是否存在性别差异。
纳入了两项随机对照试验（NCT02669394 和 NCT02737878）的 80 名老年患者的基线数据。通过颈股脉搏波速度（cf-PWV）来测量动脉僵硬度。认知功能评估包括整体认知（简易精神状态检查[MMSE]）和执行功能（转换测试[连线测试 B-A 部分]、抑制[Stroop 测试]和工作记忆[言语数字倒背测试]）。分别构建了统计模型来评估 cf-PWV 对女性和男性各认知结果的影响。每个统计模型均控制了弗雷明汉心血管疾病风险评分和教育程度。
较高的 cf-PWV 与男性的 MMSE 表现受损相关（β=-0.48；p=0.018），但与女性无关（p≥0.389）。对于执行过程，较高的 cf-PWV 与男性的连线测试 B-A 部分和 Stroop 测试受损相关（β=0.56；p=0.005；β=0.59；p=0.004），但与女性无关（p≥0.108）。cf-PWV 与男性或女性的言语数字倒背测试之间无显著相关性（p≥0.108）。
动脉僵硬度与男性的认知障碍的相关性强于女性。这些结果通过为特定性别的机制提供支持，进一步阐明了血管健康与认知功能之间的相互作用。
