*Department of Ophthalmology, Peking University Third Hospital, Beijing, China †Department of Ophthalmology, University of Louisville, Louisville, KY.
J Glaucoma. 2014 Sep;23(7):455-60. doi: 10.1097/IJG.0b013e3182946553.
To compare the interocular asymmetry of visual field loss in newly diagnosed normal-tension glaucoma (NTG), primary open-angle glaucoma (POAG), and chronic angle-closure glaucoma (CACG) patients.
Visual field results of 117 newly diagnosed, treatment-naive glaucoma patients (42 NTG, 38 POAG, and 37 CACG) were studied retrospectively. The following 3 visual field defect parameters were used to evaluate the interocular asymmetry: (1) global indices; (2) local mean deviations (MDs) of 6 predefined visual field areas; and (3) stage designated by glaucoma staging system 2. The differences of the above parameters between the trial eye (the eye with greater MDs) and the fellow eye in each subject were defined as interocular asymmetry scores.
Interocular asymmetry of visual field loss was presented in all the 3 groups (all P<0.05). CACG group had greater total MD interocular asymmetry score compared with the NTG and POAG groups (among groups, P=0.008; NTG vs. CACG, P=0.005; POAG vs. CACG, P=0.009). CACG also presented with significantly higher local MD interocular asymmetry scores at central, inferior, and temporal areas compared with those of the POAG group and at inferior area compared with that of NTG group. No significant difference in either total or local MDs was detected between NTG and POAG (all P>0.05). Interocular asymmetry scores of glaucoma staging system 2 had no significant difference among the 3 groups (P=0.068).
All CACG, POAG, and NTG groups presented with interocular asymmetric visual field loss at the time of diagnosis. CACG had greater interocular asymmetry compared with NTG and POAG. No significant interocular asymmetry difference was observed between NTG and POAG.
比较初诊正常眼压性青光眼（NTG）、原发性开角型青光眼（POAG）和慢性闭角型青光眼（CACG）患者的双眼视野缺损的眼间不对称性。
回顾性研究了 117 例初诊、未经治疗的青光眼患者（42 例 NTG、38 例 POAG 和 37 例 CACG）的视野结果。使用以下 3 种视野缺损参数来评估眼间不对称性：（1）全局指数；（2）6 个预设视野区域的局部平均偏差（MD）；（3）青光眼分期系统 2 确定的阶段。每个受试者的试验眼（MD 较大的眼）和对侧眼的上述参数差异定义为眼间不对称评分。
所有 3 组均存在视野损失的眼间不对称（均 P<0.05）。与 NTG 和 POAG 组相比，CACG 组的总 MD 眼间不对称评分更大（组间，P=0.008；NTG 与 CACG 相比，P=0.005；POAG 与 CACG 相比，P=0.009）。与 POAG 组相比，CACG 组在中央、下侧和颞侧区域的局部 MD 眼间不对称评分也显著更高，与 NTG 组相比，在下侧区域的局部 MD 眼间不对称评分也显著更高。NTG 和 POAG 之间的总 MD 和局部 MD 均无显著差异（均 P>0.05）。3 组之间的青光眼分期系统 2 的眼间不对称评分无显著差异（P=0.068）。
在初诊时，所有 CACG、POAG 和 NTG 组均表现出双眼视野损失的眼间不对称性。与 NTG 和 POAG 相比，CACG 的眼间不对称性更大。NTG 和 POAG 之间未观察到显著的眼间不对称差异。
