Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg 85764, Germany. andreas.buehler@helmholtz‑muenchen.de
Opt Lett. 2013 May 1;38(9):1404-6. doi: 10.1364/OL.38.001404.
Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first handheld MSOT imaging device with fast wavelength tuning achieving a frame rate of 50 Hz. In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers.
多光谱光声断层扫描（MSOT）具有功能和分子对比的潜力，有可能在临床实践中得到广泛应用。我们开发了第一款具有快速波长调谐功能的手持式 MSOT 成像设备，实现了 50 Hz 的帧率。在本信中，我们通过动态分辨人体志愿者中的多个与疾病相关的组织色团，包括氧合/脱氧血红蛋白和黑色素，证明了其临床潜力。
