Research, Innovation and Business Development, Guerbet, Roissy, France.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Sep-Oct;5(5):411-22. doi: 10.1002/wnan.1225. Epub 2013 Apr 30.
Superparamagnetic iron oxide (SPIO) nanoparticles are a relatively large class of contrast agents for magnetic resonance imaging. According to their biodistribution, distinct classes of SPIO nanoparticles have been investigated for clinical applications either as macrophage imaging agents or blood pool agents. Contrast agents which are pharmaceutics followed the same development rules as therapeutic drugs. Several drawbacks such as clinical development difficulties, organization of market access and imaging technological developments have limited the widespread use of these products. SPIO nanoparticles that are composed of thousands iron atoms providing large T2* effects are particularly suitable for theranostic. Stem cell migration and immune cell trafficking, as well as targeted SPIO nanoparticles for molecular imaging studies are mainly at the stage of proof of concept. A major economic challenge in the development of molecular imaging associated with a therapeutic treatment/procedure is to define innovative business models compatible with the needs of all players taking into account that theranostic solutions are promising to optimize resource allocation and ensure that expensive treatments are prescribed to responding patients.
超顺磁性氧化铁（SPIO）纳米颗粒是一类相对较大的磁共振成像对比剂。根据其生物分布，不同类别的 SPIO 纳米颗粒已被研究用于临床应用，既可作为巨噬细胞成像剂，也可作为血池造影剂。作为药物制剂的造影剂遵循与治疗药物相同的开发规则。由于临床开发困难、市场准入组织和成像技术发展等原因，这些产品的广泛应用受到限制。由数千个铁原子组成的 SPIO 纳米颗粒提供了较大的 T2*效应，特别适合于治疗诊断一体化。干细胞迁移和免疫细胞迁移，以及针对 SPIO 纳米颗粒的分子成像研究主要处于概念验证阶段。与治疗方法相关的分子成像发展的一个主要经济挑战是确定创新的商业模式，使其与所有参与者的需求保持一致，同时考虑到治疗诊断一体化解决方案有望优化资源配置并确保昂贵的治疗方法用于有反应的患者。
