Department of General, Organic & Biomedical Chemistry, NMR & Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium.
Nanomedicine (Lond). 2011 Apr;6(3):519-28. doi: 10.2217/nnm.11.16.
Magnetic iron oxide nanoparticles and their dispersion in various mediums are of wide interest for their biomedical applications and physicochemical properties. MFe(2)O(4) or MOFe(2)O(3) (where M = Co, Li, Ni or Mn, for example) can be molecularly engineered to provide a wide range of magnetic properties. In this article, we survey the literature, integrating the results of our work to give a rational view on the synthesis, physicochemical properties and applications of MFe(2)O(4), especially for MRI. However, retrieving detailed biological information on a subcellular level is difficult, owing to the limited resolution and low sensitivity of the MRI technique. Thus, this article also concentrates on the development of a magnetic iron oxide nanoparticles/quantum dot hybrids, as a dual-mode magnetic-fluorescent probe. The synthesis and physicochemical properties of the magnetic iron oxide nanoparticles/quantum dot hybrids and, especially, its application as an MRI-fluorescent probe, will also be described.
磁性氧化铁纳米粒子及其在各种介质中的分散体因其在生物医学应用和物理化学性质方面的广泛兴趣而备受关注。MFe(2)O(4)或 MOFe(2)O(3)（其中 M 可以是 Co、Li、Ni 或 Mn 等）可以通过分子工程设计来提供广泛的磁性。本文综述了文献，整合了我们工作的结果，对 MFe(2)O(4)的合成、物理化学性质和应用，特别是在 MRI 中的应用进行了合理的分析。然而，由于 MRI 技术的分辨率有限和灵敏度低，很难在亚细胞水平上获取详细的生物学信息。因此，本文还集中研究了磁性氧化铁纳米粒子/量子点杂化材料的开发，作为一种双模磁荧光探针。本文还将介绍磁性氧化铁纳米粒子/量子点杂化材料的合成和物理化学性质，特别是将其作为 MRI-荧光探针的应用。
