Department of Ophthalmology, Faculty of Medicine, Antwerp University Hospital, Antwerp University, Antwerp, Belgium.
Invest Ophthalmol Vis Sci. 2013 May 17;54(5):3505-9. doi: 10.1167/iovs.12-11441.
To study the influence of macular pigment on retinal straylight in healthy eyes.
This prospective study included 150 eyes of 75 healthy subjects between 12 and 81 years of age (mean, 46.1 years) without a history of ocular surgery or ocular disease known to influence straylight (e.g., cataract). Retinal straylight was measured with the compensation comparison technique, and the known influence of age and axial length was compensated by calculating the base, age, and axial length-corrected (BALC) straylight. Macular pigment optical density (MPOD) was measured using light-emitting diode (LED) heterochromatic flicker photometry. Axial length was determined with a partial coherence biometer and iris color by visual inspection. Data analysis consisted of studying the predictive values between these parameters, after correction for the symmetry between left and right eyes, using linear mixed models.
Mean retinal straylight was 1.05 ± 0.18 log units, and the mean MPOD was 0.37 ± 0.19. Age and axial length were found to be important predictors of retinal straylight (P < 0.001 and P = 0.010, respectively) but not of MPOD (P > 0.05). The mean BALC straylight was -0.07 ± 0.13 log units. No significant relationship was found between retinal straylight and MPOD (P > 0.05), even after correction for age and axial length. Also, no significant correlation was found between iris color and BALC straylight or MPOD.
In healthy human eyes, retinal straylight values measured with the compensation comparison technique are not significantly correlated with macular pigment optical density.
研究黄斑色素对健康眼视网膜杂散光的影响。
本前瞻性研究纳入了 150 只眼（75 名健康受试者），年龄 12 至 81 岁（平均 46.1 岁），均无眼部手术史或已知影响杂散光的眼部疾病（如白内障）。采用补偿比较技术测量视网膜杂散光，并通过计算基础、年龄和轴向长度校正（BALC）杂散光来补偿已知的年龄和眼轴长度的影响。采用发光二极管（LED）异色调频闪光光度计测量黄斑色素光密度（MPOD）。眼轴长度用部分相干光生物测量仪测定，虹膜颜色用肉眼观察。数据分析包括使用线性混合模型，在校正双眼对称性后，研究这些参数之间的预测值。
平均视网膜杂散光为 1.05±0.18 log 单位，平均 MPOD 为 0.37±0.19。年龄和眼轴长度是视网膜杂散光的重要预测因素（P<0.001 和 P=0.010），但不是 MPOD 的预测因素（P>0.05）。平均 BALC 杂散光为-0.07±0.13 log 单位。即使在校正年龄和眼轴长度后，视网膜杂散光与 MPOD 之间也没有显著相关性（P>0.05）。此外，虹膜颜色与 BALC 杂散光或 MPOD 之间也没有显著相关性。
在健康人眼中，补偿比较技术测量的视网膜杂散光值与黄斑色素光密度无显著相关性。
