Firouzbakht Mozhgan, Kiapour Azadeh, Omidvar Shabnam
Department of Nursing and Midwifery, Islamic Azad University, Babol, Iran.
J Nat Sci Biol Med. 2013 Jan;4(1):134-7. doi: 10.4103/0976-9668.107277.
Post-partum hemorrhage (PPH) is a common cause of maternal mortality in developing countries. This trial was conducted to study the effectiveness and safety of rectal misoprostol for PPH.
To assess the effectiveness and safety of misoprostol and comparing with oxytocin for prevention of PPH.
Women were randomized to receive either two 200 μg rectal misoprostol tablets (study group) or 20 units oxytocin in 1000 cc normal saline intravenously (control group). The outcomes were incidence of PPH, amount of blood loss, duration of labor, incidence of side effects, pre- and post-delivery hemoglobin, and use of additional uterotonics.
The incidence of PPH was 12% in the study group and 10% in the control group (P > 0.05). No significant difference was observed between the groups hematocrit (P > 0.05). Other variables including severe PPH and duration of the third stage of labor were similar in both groups.
Rectal misoprostol was as effective as intravenous oxytocin for preventing post-partum hemorrhage with the same incidence of side effects and is recommended to be use as an uterotonic agent to manage third stage of labor routinely.
产后出血（PPH）是发展中国家孕产妇死亡的常见原因。本试验旨在研究直肠用米索前列醇治疗产后出血的有效性和安全性。
评估米索前列醇预防产后出血的有效性和安全性，并与缩宫素进行比较。
将妇女随机分为两组，一组接受两片200μg直肠用米索前列醇片（研究组），另一组静脉注射1000cc生理盐水中含20单位缩宫素（对照组）。观察指标包括产后出血发生率、出血量、产程、副作用发生率、分娩前后血红蛋白水平以及额外宫缩剂的使用情况。
研究组产后出血发生率为12%，对照组为10%（P>0.05）。两组间血细胞比容无显著差异（P>0.05）。两组其他变量，包括严重产后出血和第三产程持续时间相似。
直肠用米索前列醇在预防产后出血方面与静脉注射缩宫素效果相同，副作用发生率也相同，建议将其作为宫缩剂常规用于处理第三产程。
