Buck Institute for Research on Aging, Novato, CA, USA.
Curr Genomics. 2012 Nov;13(7):500-7. doi: 10.2174/138920212803251454.
Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as well as to whole-transcriptome changes during the aging process or in mutants affecting aging. The value of high throughput discovery-based science in this field is clearly evident, but will it yield a true systems-level understanding of the aging process? Here we review some of this work to date, focusing on recent findings and the unanswered puzzles to which they point. In this context, we also discuss recent technological advances and some of the likely future directions that they portend.
全基因组研究涉及感兴趣的表型越来越普遍，部分原因是许多高通量技术的速度大幅提高，同时成本降低。这种基因组规模的方法已应用于寿命表型，以及在影响衰老的突变体或衰老过程中整个转录组的变化。在该领域，基于高通量发现的科学的价值是显而易见的，但它是否能真正理解衰老过程的系统水平？在这里，我们回顾了迄今为止的一些工作，重点介绍了最近的发现以及它们所指出的未解决的难题。在这种情况下，我们还讨论了最近的技术进步以及它们预示的一些可能的未来方向。
