Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses.
作者信息
Boothroyd John C
机构信息
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
PLoS Pathog. 2013;9(4):e1003296. doi: 10.1371/journal.ppat.1003296. Epub 2013 Apr 25.
Abstract
摘要
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本文引用的文献
1
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.多态拟激酶 ROP5 通过调控活性激酶 ROP18 来控制刚地弓形虫的毒力。
PLoS Pathog. 2012;8(11):e1002992. doi: 10.1371/journal.ppat.1002992. Epub 2012 Nov 8.
2
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.ROP18 的富含精氨酸的 N 端结构域对于刚地弓形虫空泡靶向和毒力是必需的。
Cell Microbiol. 2012 Dec;14(12):1921-33. doi: 10.1111/cmi.12022. Epub 2012 Sep 20.
3
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.刚地弓形虫假激酶抑制宿主 IRG 抵抗蛋白。
PLoS Biol. 2012;10(7):e1001358. doi: 10.1371/journal.pbio.1001358. Epub 2012 Jul 10.
4
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.速殖子蛋白 ROP18 和 ROP5 介导刚地弓形虫逃避鼠类而非人类干扰素-γ反应。
PLoS Pathog. 2012;8(6):e1002784. doi: 10.1371/journal.ppat.1002784. Epub 2012 Jun 28.
5
Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages.全球多样化的刚地弓形虫分离株包含六个主要的进化枝，起源于少数不同的祖先谱系。
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5844-9. doi: 10.1073/pnas.1203190109. Epub 2012 Mar 19.
6
Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hosts.宿主对弓形虫感染的转录反应因菌株而异，但在哺乳动物和禽类宿主中具有很大的保守性。
PLoS One. 2011;6(10):e26369. doi: 10.1371/journal.pone.0026369. Epub 2011 Oct 13.
7
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.刚地弓形虫棒状体蛋白激酶 ROP16 激活 STAT3 和 STAT6，导致细胞因子抑制和依赖精氨酸酶-1 的生长控制。
PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.
8
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.ATF6β 是刚地弓形虫毒力因子 ROP18 的宿主细胞靶标。
J Exp Med. 2011 Jul 4;208(7):1533-46. doi: 10.1084/jem.20101660. Epub 2011 Jun 13.
9
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.刚地弓形虫多态效应物决定巨噬细胞极化和肠道炎症。
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10
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.家族中一系列多态假激酶的扩增导致弓形虫毒力差异。
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. doi: 10.1073/pnas.1015338108. Epub 2011 May 17.
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