Casimiro Mathew C, Crosariol Marco, Loro Emanuele, Li Zhiping, Pestell Richard G
Thomas Jefferson University, Philadelphia, PA, USA.
Genes Cancer. 2012 Nov;3(11-12):649-57. doi: 10.1177/1947601913479022.
Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis. Recent studies have demonstrated that cyclin D1 conducts additional specific functions to regulate gene expression in the context of local chromatin, promote cellular migration, and promote chromosomal instability. It is anticipated that these additional functions contribute to the pathology associated with dysregulated cyclin D1 abundance. This article discusses evidence that examines the functional roles that cyclin D1 may play in cancer with an emphasis on other cyclin family members that also may contribute to cancer and disease in a similar fashion.
在超过50%的人类乳腺癌中发现细胞周期蛋白D1过表达，并且在转基因小鼠中会引发乳腺癌。细胞周期蛋白D1基因表达或功能失调会导致肿瘤发生过程中正常细胞周期控制的丧失。最近的研究表明，细胞周期蛋白D1在局部染色质环境中具有调节基因表达、促进细胞迁移和促进染色体不稳定的额外特定功能。预计这些额外功能会导致与细胞周期蛋白D1丰度失调相关的病理学变化。本文讨论了相关证据，这些证据检验了细胞周期蛋白D1在癌症中可能发挥的功能作用，重点关注其他也可能以类似方式导致癌症和疾病的细胞周期蛋白家族成员。
