Sallam Khaled, Amr Mostafa
Assistant Professor, Department of Neurology, Faculty of Medicine, Benha University , Egypt .
J Clin Diagn Res. 2013 Mar;7(3):484-8. doi: 10.7860/JCDR/2013/4203.2803. Epub 2013 Mar 1.
An early and a quick identification of dementia is desirable to improve the overall care to the affected persons in the developing countries. The aim of this study was to evaluate the discriminative abilities of the Mini Mental State Examination (MMSE) and the Clock Drawing Test (CDT) in differentiating the demented patients from the controls and also the differentiation between the different types of dementia.
This study was designed to evaluate the patients with varied types and severities of dementia, who were diagnosed by using the Clinical Dementia Rating (CDR) scale. All the patients completed the MMSE and the simplified CDT.
This study included 197 patients with an age range of 43-79 years. Fifty-one patients (25.9%) were diagnosed with Alzheimer Dementia (AD), 37 patients (18.8%) with Vascular Dementia (VD), 23 patients (11.7%) with Parkinson's Disease Dementia (PDD) and 86 patients (43.6%) with other variants of dementia. The total MMSE score of the enrolled patients was significantly lower as compared to that of the control subjects, with a non-significant difference between the varied diagnoses. The total CDT scores were significantly lower in the patients as compared to those in the controls, with significantly lower scores in the PDD group as compared to those in the AD group. The patients who had AD showed non-significantly higher CDT scores as compared to the patients who had vascular and other types of dementia.
A combined application of both MMSE and CDT can identify the persons with a cognitive affection and this may be a useful tool for the diagnosis of the non Alzheimer's type of dementia.
在发展中国家,尽早且快速地识别痴呆症有助于改善对患者的整体护理。本研究的目的是评估简易精神状态检查表(MMSE)和画钟试验(CDT)在区分痴呆患者与对照组以及不同类型痴呆之间的鉴别能力。
本研究旨在评估使用临床痴呆评定量表(CDR)诊断的不同类型和严重程度的痴呆患者。所有患者均完成了MMSE和简化版CDT。
本研究纳入了197例年龄在43至79岁之间的患者。51例(25.9%)被诊断为阿尔茨海默病性痴呆(AD),37例(18.8%)为血管性痴呆(VD),23例(11.7%)为帕金森病性痴呆(PDD),86例(43.6%)为其他类型的痴呆。与对照组相比,纳入患者的MMSE总分显著更低,不同诊断之间无显著差异。与对照组相比,患者的CDT总分显著更低,PDD组的分数与AD组相比显著更低。与患有血管性痴呆和其他类型痴呆的患者相比,患有AD的患者CDT分数略高,但差异不显著。
MMSE和CDT联合应用可以识别认知障碍患者,这可能是诊断非阿尔茨海默病性痴呆的有用工具。