Wucherer Katja L, Conzemius Michael G, Evans Richard, Wilke Vicki L
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
J Am Vet Med Assoc. 2013 May 15;242(10):1364-72. doi: 10.2460/javma.242.10.1364.
To determine short- and long-term rates of successful outcomes of surgical and nonsurgical treatments for overweight dogs with cranial cruciate ligament rupture (CCLR).
Prospective, randomized, clinical trial. Animals-40 client-owned overweight dogs with unilateral CCLR.
Dogs were randomly assigned to nonsurgical (physical therapy, weight loss, and NSAID administration) or surgical (tibial plateau leveling osteotomy) treatment groups; dogs in both groups received the same nonsurgical treatments. Dogs were evaluated immediately before and 6, 12, 24, and 52 weeks after initiation of treatments via owner questionnaires, gait analysis, and dual-energy x-ray absorptiometry. A successful outcome was defined as an affected limb net ground reaction force > 85% of the value for healthy dogs and a ≥ 10% improvement in values of questionnaire variables.
Owner questionnaire responses indicated dogs in both groups improved during the study, but dogs in the surgical treatment group seemed to have greater improvement. Body fat percentages for dogs in both treatment groups significantly decreased during the study. Surgical treatment group dogs had significantly higher peak vertical force for affected limbs versus nonsurgical treatment group dogs at the 24- and 52-week evaluation times. Surgical treatment group dogs had a higher probability of a successful outcome (67.7%, 92.6%, and 75.0% for 12-, 24-, and 52-week evaluations, respectively) versus nonsurgical treatment group dogs (47.1%, 33.3%, and 63.6% for 12-, 24-, and 52-week evaluations, respectively).
Overweight dogs with CCLR treated via surgical and nonsurgical methods had better outcomes than dogs treated via nonsurgical methods alone. However, almost two-thirds of the dogs in the nonsurgical treatment group had a successful outcome at the 52-week evaluation time.
确定超重犬颅交叉韧带断裂（CCLR）的手术和非手术治疗的短期和长期成功结局发生率。
前瞻性、随机临床试验。动物——40只客户拥有的单侧CCLR超重犬。
将犬随机分为非手术组（物理治疗、减重和非甾体抗炎药给药）或手术组（胫骨平台水平截骨术）；两组犬均接受相同的非手术治疗。通过主人问卷、步态分析和双能X线吸收法在治疗开始前以及治疗开始后6、12、24和52周对犬进行评估。成功结局定义为患侧肢体净地面反作用力>健康犬值的85%且问卷变量值提高≥10%。
主人问卷回复表明两组犬在研究期间均有改善，但手术治疗组犬的改善似乎更大。两个治疗组犬的体脂百分比在研究期间均显著下降。在24周和52周评估时，手术治疗组患侧肢体的峰值垂直力显著高于非手术治疗组犬。与非手术治疗组犬相比，手术治疗组犬获得成功结局的概率更高（12周、24周和52周评估时分别为67.7%、92.6%和75.0%），而非手术治疗组犬在12周、24周和52周评估时分别为47.1%、33.3%和63.6%。
采用手术和非手术方法治疗的CCLR超重犬比仅采用非手术方法治疗的犬结局更好。然而，在52周评估时，非手术治疗组几乎三分之二的犬获得了成功结局。
