Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Med Phys. 2013 May;40(5):050901. doi: 10.1118/1.4802733.
Approaches to imaging the breast with nuclear medicine and∕or molecular imaging methods have been under investigation since the late 1980s when a technique called scintimammography was first introduced. This review charts the progress of nuclear imaging of the breast over the last 20 years, covering the development of newer techniques such as breast specific gamma imaging, molecular breast imaging, and positron emission mammography. Key issues critical to the adoption of these technologies in the clinical environment are discussed, including the current status of clinical studies, the efforts at reducing the radiation dose from procedures associated with these technologies, and the relevant radiopharmaceuticals that are available or under development. The necessary steps required to move these technologies from bench to bedside are also discussed.
自 20 世纪 80 年代末首次引入一种名为闪烁乳腺成像术的技术以来，核医学和/或分子成像方法在乳腺成像方面的研究一直在进行。本综述概述了过去 20 年来乳腺核成像的进展，涵盖了新技术的发展，如乳腺特异性γ成像、分子乳腺成像和正电子发射乳腺断层摄影术。讨论了这些技术在临床环境中应用的关键问题，包括临床研究的现状、降低与这些技术相关的程序辐射剂量的努力，以及现有的或正在开发的相关放射性药物。还讨论了将这些技术从实验室推向临床所必需的步骤。
