Infertility Research Unit, Société de Recherche pour l'Infertilité, Brussels, Belgium.
Fertil Steril. 2013 May;99(6):1503-13. doi: 10.1016/j.fertnstert.2013.03.030.
Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports the results of 60 orthotopic reimplantations of cryopreserved ovarian tissue performed by three teams, as well as 24 live births reported in the literature to date. Restoration of ovarian activity occurred in almost all cases in the three series. Among the 60 patients, eleven conceived and six of those had already delivered twelve healthy babies. In the future, we are looking to: 1) improve freezing techniques; and 2) enhance the "vascular bed" before reimplantation to increase pregnancy rates. On the other hand, cryopreservation of ovarian tissue may be combined with removal, via puncture, of small antral follicles, making it possible to freeze both ovarian tissue and isolated immature oocytes.
积极的化疗/放疗和骨髓移植可以治愈 >90%的患有需要此类治疗的疾病的女孩和年轻女性。然而，卵巢对细胞毒性药物非常敏感，尤其是烷化剂。目前有几种选择可以在癌症患者中保留生育能力。本综述报告了三个团队进行的 60 例冷冻保存卵巢组织的原位再植入的结果，以及迄今为止文献中报道的 24 例活产。在三个系列中，几乎所有情况下卵巢活动都得到了恢复。在 60 名患者中，有 11 名患者怀孕，其中 6 名患者已经分娩了 12 名健康婴儿。未来，我们希望：1）改进冷冻技术；2）在再植入前增强“血管床”，以提高妊娠率。另一方面，卵巢组织的冷冻保存可以与通过穿刺取出小窦卵泡相结合，从而可以冷冻卵巢组织和分离的不成熟卵母细胞。
