肝脏祖细胞的分化：局部选择的问题。
Differentiation of progenitors in the liver: a matter of local choice.
机构信息
Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
出版信息
J Clin Invest. 2013 May;123(5):1867-73. doi: 10.1172/JCI66026. Epub 2013 May 1.
Abstract
The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.
摘要
肝脏是一个复杂的器官，在其整个生命周期的发育和稳态过程中都需要进行多轮细胞命运决定。在器官发生的早期阶段，肝脏从胰腺和肠道中获得了一个独立的谱系，随后，肝芽必须适当分化，形成代谢性肝细胞和胆管细胞，以维持正常的肝脏生理功能。此外，在整个生命周期中，肝脏会受到化学和病理损伤的侵袭，这就需要激活和正确分化成体祖细胞。本综述旨在概述允许这些严格调控过程发生的复杂信号关系。
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