皮肤创伤和疾病修复过程中的缝隙连接重塑。
Gap junction remodeling in skin repair following wounding and disease.
机构信息
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.
出版信息
Physiology (Bethesda). 2013 May;28(3):190-8. doi: 10.1152/physiol.00058.2012.
PMID:23636264
Abstract
In the present review, we provide an overview of connexin expression during skin development and remodeling in wound healing, and reflect on how loss- or gain-of-function connexin mutations may change cellular phenotypes and lead to diseases of the skin. We also consider the therapeutic value of targeting connexins in wound healing.
摘要
在本综述中，我们概述了连接蛋白在皮肤发育和伤口愈合中的重塑过程中的表达，并思考了连接蛋白突变的功能丧失或获得如何改变细胞表型并导致皮肤疾病。我们还考虑了在伤口愈合中靶向连接蛋白的治疗价值。
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