Aasen Trond
Molecular Pathology Group, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain,
Cell Tissue Res. 2015 Jun;360(3):685-99. doi: 10.1007/s00441-014-2078-3. Epub 2014 Dec 31.
Mounting evidence indicates that dysregulation of gap junctions and their structural subunits-connexins-often occurs in, and sometimes causes, a variety of proliferative disorders, including cancer. Connexin-mediated regulation of cell proliferation is complex and may involve modulation of gap junction intercellular communication (GJIC), hemichannel signalling, or gap junction-independent paths. However, the exact mechanisms linking connexins to proliferation remain poorly defined and a number of contradictory studies report both pro- and anti-proliferative effects, effects that often depend on the cell or tissue type or the microenvironment. The present review covers junctional and non-junctional regulation of proliferation by connexins, with a particular emphasis on their association with cancer.
越来越多的证据表明，间隙连接及其结构亚基——连接蛋白的失调经常发生在包括癌症在内的多种增殖性疾病中，有时甚至会引发这些疾病。连接蛋白介导的细胞增殖调节是复杂的，可能涉及间隙连接细胞间通讯（GJIC）的调节、半通道信号传导或不依赖间隙连接的途径。然而，连接蛋白与增殖之间的确切机制仍不清楚，许多相互矛盾的研究报告了其促增殖和抗增殖作用，这些作用往往取决于细胞或组织类型或微环境。本综述涵盖了连接蛋白对增殖的连接性和非连接性调节，特别强调了它们与癌症的关联。
