University of Warwick, Department of Chemistry, Gibbet Hill Road, Warwick, UK.
Chem Commun (Camb). 2013 Jun 7;49(45):5106-31. doi: 10.1039/c3cc41143e.
Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative agents, as well as in the design of metal-based diagnostic agents. Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis. Examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.
金属药物基于金属的选择、其氧化态、配位配体的类型和数量以及配位几何结构，为药物作用的独特机制提供了潜力。我们讨论了在确定新的靶标位点和阐明抗癌、抗菌、抗病毒、抗寄生虫、抗炎和神经退行性疾病药物以及金属基诊断剂的作用机制方面的最新进展。蛋白质组学、基因组学和金属形态分析的进展加速了靶标识别和定义的进展。突出显示了目前在临床使用、临床试验或临床前开发中的金属化合物和螯合剂（酶抑制剂）的例子。
