School of Biology and Chemical Engineering, Zhejiang University of Science and Technology, 318# Liu He Lu, Hangzhou, 310023, Zhejiang, China.
Biotechnol Lett. 2013 Aug;35(8):1309-15. doi: 10.1007/s10529-013-1206-6. Epub 2013 May 1.
Blakeslea trispora powder that contains 1.9 % lycopene was tested for its anti-aging effect on adult mice. 48 adult mice were administered with the powder at 0, 267, 534, 1,068 mg lycopene kg(-1) body daily for 30 days. The body weight, hematology, clinical chemical and antioxidant activities in major organs of adult mice were measured. The powder had no effect on the body weight, hematology, clinical chemical parameters of adult mice but improved the antioxidant activities in major organs of adult mice. Increased activities of superoxide dismutase, catalase and glutathione peroxidase and a decreased amount of malondialdehyde in liver, brain, kidney and skin of adult mice when a high-dose of the B. trispora powder was administered, suggests that it has the ability to enhance the antioxidation system and improve the anti-aging abilities of adult mice.
对含有 1.9%番茄红素的布拉氏小球藻粉进行了抗衰老作用的研究。48 只成年小鼠连续 30 天每天分别灌胃给予 0、267、534、1068mg/kg 番茄红素剂量的布拉氏小球藻粉，检测成年小鼠体重、血液学、临床生化及主要器官抗氧化活性。该粉对成年小鼠体重、血液学、临床生化参数均无影响，但可提高成年小鼠主要器官的抗氧化活性。当给予高剂量布拉氏小球藻粉时，成年小鼠肝、脑、肾和皮肤中超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性升高，丙二醛含量降低，表明其具有增强抗氧化系统和提高成年小鼠抗衰老能力的作用。
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