Ganesan Palanivel, Choi Dong-Kug
Department of Applied Life Science, Nanotechnology Research Center, Chungju, Republic of Korea; Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea.
Int J Nanomedicine. 2016 May 11;11:1987-2007. doi: 10.2147/IJN.S104701. eCollection 2016.
Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.
植物化合物已在药妆品中使用了数十年，并已显示出在美容应用方面的潜力，包括防晒、保湿、抗老化以及基于皮肤的治疗。使用植物基药妆品的主要问题是各种化妆品的渗透率较低以及化合物稳定性高，难以持续并增强化合物向基于皮肤的美容治疗的递送。为了克服这些缺点，目前纳米级递送技术被用于在药妆品领域和产品中持续并增强植物源生物活性化合物的递送。植物化合物的纳米化增强了各种药妆品的无菌感，具有持续递送和增强的皮肤保护活性。固体脂质纳米粒、传递体、醇质体、纳米结构脂质载体、富勒烯和碳纳米管是目前正在使用的一些新兴纳米技术，用于在皮肤护理中增强植物化合物的递送。芦荟、姜黄素、白藜芦醇、槲皮素、维生素C和E、染料木黄酮以及绿茶儿茶素已通过各种递送技术成功纳米化，并被纳入各种用于皮肤、嘴唇和头发护理的凝胶、乳液和面霜中，以发挥其持续效果。然而，某些递送剂，如碳纳米管，需要研究其在毒性方面的作用。本综述广泛关注植物化合物在各种药妆品中的使用、用于将植物化合物递送至各种药妆品的纳米递送技术，以及用于开发新型纳米药妆品以增强基于皮肤的治疗的各种纳米级植物化合物。
