School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Muscle Nerve. 2013 Aug;48(2):219-25. doi: 10.1002/mus.23726. Epub 2013 May 2.
Electrical stimulation of denervated muscle has been shown to minimize atrophy and fibrosis and increase force in animal and human models. However, electrical stimulation after nerve repair is controversial due to questions of efficacy.
Using a rat model, we investigated the efficacy of short-term electrical muscle stimulation for increasing reinnervation and preventing muscle atrophy. After tibial nerve transection and immediate repair with the fibular nerve, 1 month of electrical stimulation was applied 5 days/week for 1 hour to the gastrocnemius muscle via implanted electrodes.
After 2 months of further recovery without stimulation, muscle weights, twitch forces, and type I fiber areas were significantly greater in stimulated animals than in repaired controls without stimulation. Motor unit size and numbers were not different between the 2 groups.
Short-term electrical muscle stimulation after nerve repair significantly reduces muscle atrophy and does not affect motor reinnervation.
去神经肌肉的电刺激已被证明可最小化萎缩和纤维化，并增加动物和人体模型中的力量。然而，由于疗效的问题，神经修复后的电刺激仍存在争议。
使用大鼠模型，我们研究了短期电肌肉刺激增加神经再支配和预防肌肉萎缩的效果。在胫神经切断后，立即用腓神经修复，通过植入的电极将电刺激施加到腓肠肌，每周 5 天，每天 1 小时，持续 1 个月。
在没有刺激的进一步恢复 2 个月后，与未接受刺激的修复对照组相比，接受刺激的动物的肌肉重量、抽搐力和 I 型纤维面积显著更大。两组的运动单位大小和数量没有差异。
神经修复后短期电肌肉刺激可显著减少肌肉萎缩，且不会影响运动神经再支配。
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