脓毒症患者血清对氧磷酶和芳基酯酶活性的预后价值
Prognostic value of serum paraoxonase and arylesterase activity in patients with sepsis.
作者信息
Li Yunhui, Zhai Rubo, Li Haifeng, Mei Xu, Qiu Guangbin
机构信息
Clinical Laboratory Department, No. 202 Hospital of Chinese People's Liberation Army, Shenyang, Liaoning, China.
出版信息
J Int Med Res. 2013 Jun;41(3):681-7. doi: 10.1177/0300060513483412. Epub 2013 May 1.
OBJECTIVE
To determine whether serum paraoxonase (PON) and arylesterase (ARE) activity might predict sepsis mortality.
METHODS
Patients with sepsis and healthy control subjects were enrolled in this retrospective study. Serum PON and ARE activity levels were measured. Patients were stratified according to 30-day mortality rates.
RESULTS
Serum PON and ARE activity levels were significantly lower in patients with sepsis (n = 61) than in healthy controls (n = 32), and were significantly lower in nonsurviving patients (n = 22) than in surviving patients (n = 39). Low PON and ARE activity levels were significantly correlated with poor overall survival in patients with sepsis.
CONCLUSIONS
Decreased serum PON and ARE activity is related to poor prognosis in patients with sepsis. Measuring the activity of PON and ARE may represent a new method for evaluating the prognosis of sepsis. In addition, both PON and ARE are potential molecular treatment targets for sepsis.
目的
确定血清对氧磷酶（PON）和芳基酯酶（ARE）活性是否可预测脓毒症死亡率。
方法
本回顾性研究纳入了脓毒症患者和健康对照者。检测血清PON和ARE活性水平。根据30天死亡率对患者进行分层。
结果
脓毒症患者（n = 61）的血清PON和ARE活性水平显著低于健康对照者（n = 32），非存活患者（n = 22）的血清PON和ARE活性水平显著低于存活患者（n = 39）。低PON和ARE活性水平与脓毒症患者的总体生存不良显著相关。
结论
血清PON和ARE活性降低与脓毒症患者预后不良有关。检测PON和ARE活性可能代表一种评估脓毒症预后的新方法。此外，PON和ARE均是脓毒症潜在的分子治疗靶点。
Zotero 插件