Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, Sweden.
PLoS One. 2013 Apr 18;8(4):e61466. doi: 10.1371/journal.pone.0061466. Print 2013.
Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.
Nested cross-sectional study.
Forty subfertile biochemically hypogonadal (n = 20) or eugonadal (n = 20) men (mean age 37 years, SD = 4.3) and 20 age-matched controls were randomly selected from an ongoing study on male subfertility. Subjects comprised male partners in infertile couples in whom also subnormal sperm concentration was present. Blood sampling, interviews, and anthropometric measures were undertaken. Serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI-markers were assessed.
Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = -0.025; p = 0.028), 1-beta (MIP1B) (ß = -0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = -0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = -1.95; p = 0.001) and TNFa (ß = -0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels. Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT (mean ratio 1.84; p = 0.030).
Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.
在老年男性中，低度系统性炎症（LGSI）和雄激素缺乏与多种病理有关，包括心血管疾病（CVD）。我们想研究一下，在任何 CVD 或其他系统性疾病的并发表现之前，低睾丸激素水平是否与年轻男性的 LGSI 生物标志物有关。
嵌套的横断面研究。
从一项正在进行的男性不育研究中，随机选择了 40 名生化性低促性腺激素（n=20）或促性腺激素正常（n=20）的不育男性（平均年龄 37 岁，标准差=4.3）和 20 名年龄匹配的对照组。受试者包括不育夫妇中精子浓度也不正常的男性伴侣。进行了血液采样、访谈和人体测量。评估了血清睾酮、LH、雌二醇、SHBG 和 21 种 LGSI 标志物的水平。
在 21 种炎症标志物中，巨噬细胞炎性蛋白 1-α（MIP1a）（β=-0.025；p=0.028）、1-β（MIP1B）（β=-0.015；p=0.049）和肿瘤坏死因子-α（TNFa）（β=-0.015；p=0.040）与总睾酮（TT）水平呈负相关。MIP1a（β=-1.95；p=0.001）和 TNFa（β=-0.95；p=0.014）与计算的游离睾酮（cFT）水平呈负相关。与 TT 和 cFT 水平正常的男性相比，TT 水平低下的男性 TNFa 水平更高（平均比值 1.61；p=0.006），cFT 水平低下的男性 TNFa 水平更高（平均比值 1.58；p=0.007）。此外，TT 水平低下的男性 MIP1a 水平也更高（平均比值 1.84；p=0.030）。
在年轻男性中，睾丸激素水平低下可能已经与 LGSI 有关，这可能是男性性腺功能减退不良健康后果的机制之一。
