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子宫内膜异位症:管理方面的最新进展

Endometriosis: an update on management.

作者信息

Bernardi Lia A, Pavone Mary Ellen

机构信息

Department of Obstetrics & Gynecology, University of Illinois at Chicago, IL 60611, USA.

出版信息

Womens Health (Lond). 2013 May;9(3):233-50. doi: 10.2217/whe.13.24.

Abstract

Endometriosis is an inflammatory disease that commonly occurs in women of reproductive age and is associated with pain and infertility. This disease can be challenging to manage given its propensity to progress and recur despite treatment. Although medical therapy is beneficial for controlling pain due to endometriosis, medical management has not proven to be effective in treating infertility resulting from endometriosis. Surgery has historically been performed to both improve pain and treat infertility in women with endometriosis. However, the optimal management of endometriosis in asymptomatic women who desire fertility is unclear. Intrauterine insemination with superovulation and IVF are other treatments that have proven to be effective in assisting women with endometriosis to conceive. As the underlying molecular mechanisms of this disease become better understood, promising new therapies for the treatment of endometriosis continue to be investigated.

摘要

子宫内膜异位症是一种炎症性疾病,常见于育龄女性,与疼痛和不孕有关。鉴于其即使在治疗后仍有进展和复发的倾向,这种疾病的管理可能具有挑战性。虽然药物治疗有助于控制子宫内膜异位症引起的疼痛,但尚未证明药物治疗对治疗由子宫内膜异位症导致的不孕有效。从历史上看,手术一直用于改善患有子宫内膜异位症女性的疼痛并治疗其不孕问题。然而,对于渴望生育的无症状子宫内膜异位症女性的最佳管理尚不清楚。宫腔内人工授精联合超排卵以及体外受精是已被证明在协助患有子宫内膜异位症的女性受孕方面有效的其他治疗方法。随着对这种疾病潜在分子机制的理解不断深入,仍在继续研究有前景的子宫内膜异位症新疗法。

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