Department of Physical Therapy, China Medical University, Taichung, Taiwan.
Reg Anesth Pain Med. 2013 Jul-Aug;38(4):282-8. doi: 10.1097/AAP.0b013e31828df3f9.
Exercise creates a variety of psychophysical effects, including altered pain perception. We investigated whether physical exercise reduces postincisional pain and cytokine and N-methyl-D-aspartate receptor 1 (NR1) expression in a rat model of skin/muscle incision and retraction (SMIR)-evoked pain.
Male Sprague-Dawley rats were divided randomly into 4 groups: sham operated, SMIR-sedentary (SS), SMIR-exercise, and sham operated-exercise. On postoperative day 8, trained rats started to run on a treadmill 55 min/d with an intensity of 18 meter/minute (m/min), 5 days per week for 4 weeks. NR1, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) expressions in the spinal cord as well as mechanical hypersensitivity following SMIR surgery were assessed for 6 to 35 days.
On postoperative day 6, SMIR-sedentary rats exhibited a marked hypersensitivity to von Frey stimuli. By contrast, SMIR-operated rats undergoing exercise demonstrated a quick recovery of mechanical hypersensitivity. The levels of TNF-α, IL-6, and NR1 in the spinal cord were significantly increased in SS rats when compared with sham-operated rats on postoperative days 6, 21, and 35 after SMIR surgery. After the 4-week exercise intervention, the SMIR-exercise group showed lower NR1, TNF-α, and IL-6 expression in the spinal cord than those in the SS group.
These results suggest that exercise training decreases persistent postsurgical pain caused by SMIR surgery. There appears to be a protective effect, probably relating to the decrease of NR1, TNF-α, and IL-6 expression in the spinal cord of SMIR rats, after exercise intervention.
运动产生多种身心效应，包括改变疼痛感知。我们研究了运动是否能减轻切口和肌肉牵拉（SMIR）诱发疼痛的大鼠模型中的术后疼痛以及细胞因子和 N-甲基-D-天冬氨酸受体 1（NR1）的表达。
雄性 Sprague-Dawley 大鼠随机分为 4 组：假手术组、SMIR 静息组（SS）、SMIR 运动组和假手术运动组。术后第 8 天，训练大鼠开始以 18 米/分钟（m/min）的强度在跑步机上每天跑 55 分钟，每周 5 天，持续 4 周。评估 SMIR 手术后 6 至 35 天脊髓中 NR1、肿瘤坏死因子-α（TNF-α）和白细胞介素 6（IL-6）的表达以及机械性超敏反应。
术后第 6 天，SMIR 静息组大鼠对冯弗雷斯特刺激表现出明显的超敏反应。相比之下，接受运动的 SMIR 手术大鼠表现出机械性超敏反应的快速恢复。与假手术组相比，SMIR 手术 6、21 和 35 天后 SS 大鼠脊髓中的 TNF-α、IL-6 和 NR1 水平显著升高。经过 4 周的运动干预后，SMIR 运动组大鼠脊髓中 NR1、TNF-α 和 IL-6 的表达均低于 SS 组。
这些结果表明，运动训练可减轻 SMIR 手术引起的持续性术后疼痛。运动干预后，SMIR 大鼠脊髓中 NR1、TNF-α 和 IL-6 的表达降低，可能存在保护作用。
