Department of Obstetrics and Gynecology, School of Medicine, Dicle University, Diyarbakir, Turkey.
Eur Rev Med Pharmacol Sci. 2013 Apr;17(7):874-8.
To examine placental expression of vimentin and desmin in relation to ultrastructural changes within the placental villi in cases of HELLP syndrome.
Formaldehyde-fixed and paraffin-embedded specimens of 15 healthy pregnant and 13 Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, placentas were used for Harris hematoxylin staining, vimentin and desmin immunohistochemistry, and transmission electron microscopy (TEM).
Increased of fibrinoid necrosis in vascular wall and the periphery of villi were observed in sections of the placentas with HELLP syndrome. Increased expression of vimentin in the intravillous area and increased expression of desmin on blood vessel wall, were seen in placentas of patients with HELLP syndrome when compared to placentas of healthy pregnant.
Augmentation of intermediate filaments, desmin, vimentin may disturb normal movements of endothelial cells, and may display placental dysfunction that is unable to compensate the endothelial instability and the related hypertension in HELLP syndrome. Further studies are needed to get more definit results and also to compare HELLP syndrome with preeclampsia.
探讨在 HELLP 综合征患者胎盘绒毛中，波形蛋白和结蛋白的表达与胎盘绒毛超微结构变化的关系。
使用福尔马林固定和石蜡包埋的 15 例正常妊娠和 13 例溶血性贫血、肝酶升高和血小板计数降低（HELLP）综合征胎盘标本，进行 Harris 苏木精染色、波形蛋白和结蛋白免疫组化及透射电镜检查。
HELLP 综合征胎盘切片中观察到血管壁和绒毛周边纤维蛋白样坏死增加。与正常妊娠胎盘相比，HELLP 综合征胎盘绒毛内区波形蛋白表达增加，血管壁结蛋白表达增加。
中间丝、结蛋白和波形蛋白的增加可能干扰内皮细胞的正常运动，并表现出胎盘功能障碍，无法代偿 HELLP 综合征中内皮不稳定和相关高血压。需要进一步研究以获得更明确的结果，并将 HELLP 综合征与子痫前期进行比较。
