Evsen Mehmet Siddik, Kalkanli Sevgi, Deveci Engin, Sak Muhammet Erdal, Ozler Ali, Baran Ozlem, Erdem Elif, Seker Uğur
Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey.
Anal Quant Cytopathol Histpathol. 2013 Oct;35(5):283-8.
To evaluate Hofbauer cells in the placentas of women diagnosed with HELLP syndrome.
The present study compared 20 patients with HELLP syndrome and 20 control patients with respect to demographics, hematological parameters and the presence of Hofbauer cells in placental samples. CD-68 antibody was used for immunohistochemical examination. The total number and size of Hofbauer cells were measured in the placental villi, and the proportion of Hofbauer cells relative to the vascular structure was also compared between groups.
The patient and control groups were similar according to baseline obstetric characteristics. White blood cell counts in patients with HELLP syndrome and the control group were 15,139 +/- 4,169 and 10,806 +/- 2,888, respectively, and were significantly increased among patients with HELLP syndrome (p < 0.001). Hofbauer cell numbers in the placental villi of patients with HELLP syndrome were significantly elevated in comparison to normotensive controls (p = 0.046). The proportion of Hofbauer cells in the placental villi according to proximity to the vascular structure were 3.85 +/- 1.66 in the HELLP group and 1.75 +/- 1.12 in controls (p < 0.001). Sizes of the Hofbauer cells were not statistically different between groups.
Increased Hofbauer cells may be associated with increased inflammation or may have an adaptive mechanism at the fetal site of the placenta in patients with HELLP syndrome.
评估诊断为HELLP综合征的女性胎盘组织中的霍夫鲍尔细胞。
本研究比较了20例HELLP综合征患者和20例对照患者的人口统计学特征、血液学参数以及胎盘样本中霍夫鲍尔细胞的存在情况。采用CD-68抗体进行免疫组化检查。测量胎盘绒毛中霍夫鲍尔细胞的总数和大小，并比较两组中霍夫鲍尔细胞相对于血管结构的比例。
根据基线产科特征，患者组和对照组相似。HELLP综合征患者和对照组的白细胞计数分别为15,139±4,169和10,806±2,888，HELLP综合征患者的白细胞计数显著升高（p<0.001）。与血压正常的对照组相比，HELLP综合征患者胎盘绒毛中的霍夫鲍尔细胞数量显著增加（p=0.046）。根据与血管结构的接近程度，HELLP组胎盘绒毛中霍夫鲍尔细胞的比例为3.85±1.66，对照组为1.75±1.12（p<0.001）。两组之间霍夫鲍尔细胞的大小无统计学差异。
霍夫鲍尔细胞增多可能与炎症增加有关，或者在HELLP综合征患者胎盘的胎儿部位具有一种适应性机制。
