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在减肥维持试验中，体重减轻量随年龄增加而增加。

Greater weight loss with increasing age in the weight loss maintenance trial.

机构信息

Division of Nephrology/Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Hypertension Center and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.

出版信息

Obesity (Silver Spring). 2014 Jan;22(1):39-44. doi: 10.1002/oby.20506. Epub 2013 Jul 29.

DOI:10.1002/oby.20506
PMID:23640912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3849225/
Abstract

OBJECTIVE

To determine the effect of age on weight loss and weight loss maintenance in participants in the Weight Loss Maintenance trial (WLM).

DESIGN AND METHODS

Secondary analysis of a randomized controlled trial of overweight/obese adults with CVD risk factors was conducted. Participants were 1685 adults with baseline BMI 25-45 kg m(2) with hypertension and/or dyslipidemia. Those who lost at least 4kg in an initial 6-month behavioral weight loss intervention (N = 1,032) were randomly assigned to a 30-month maintenance phase of self-directed control (SD), monthly personal counseling (PC), or unlimited access to an internet-based intervention (IT). Age groups were defined post-hoc and weight change was compared among age groups.

RESULTS

Participants ≥60 years old initially lost more weight than younger individuals, and sustained greater weight loss in IT and PC but not in SD (P value for trend 0.024, 0.002, and 0.36, respectively).

CONCLUSIONS

In WLM, adults age ≥60 years had greater initial weight loss and greater sustained weight loss over 3 years, compared to younger adults. Older adults had greater weight loss maintenance with either personal counseling or internet-based intervention. Future research should determine optimal implementation strategies and effects of weight loss on health outcomes in older adults.

摘要

目的

在体重维持试验（WLM）中，确定年龄对参与者减肥和体重维持的影响。

设计和方法

对伴有 CVD 危险因素的超重/肥胖成年人的一项随机对照试验进行二次分析。参与者为 1685 名基线 BMI 为 25-45 kg m(2)、患有高血压和/或血脂异常的成年人。在最初的 6 个月行为减肥干预中至少减轻 4kg 的人（N=1032）被随机分配到 30 个月的自我指导控制（SD）、每月个人咨询（PC）或无限制访问基于互联网的干预（IT）维持阶段。事后定义了年龄组，并比较了不同年龄组之间的体重变化。

结果

≥60 岁的参与者最初比年轻个体减轻更多的体重，并且在 IT 和 PC 中维持更大的体重减轻，但在 SD 中则不然（趋势检验 P 值分别为 0.024、0.002 和 0.36）。

结论

在 WLM 中，与年轻成年人相比，年龄≥60 岁的成年人初始体重减轻更多，并且在 3 年内持续体重减轻更多。老年人通过个人咨询或基于互联网的干预，体重维持效果更好。未来的研究应该确定在老年人中实施这些策略的最佳方案以及减肥对健康结果的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63e3/3849225/c11f45b4a579/nihms472470f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63e3/3849225/207d4e81f5bc/nihms472470f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63e3/3849225/c11f45b4a579/nihms472470f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63e3/3849225/207d4e81f5bc/nihms472470f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63e3/3849225/c11f45b4a579/nihms472470f2.jpg

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