传染病遗传流行病学研究中的家庭接触研究设计。
The household contact study design for genetic epidemiological studies of infectious diseases.
机构信息
Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA ; Uganda - Case Western Reserve University Research Collaboration Kampala, Uganda.
出版信息
Front Genet. 2013 Apr 30;4:61. doi: 10.3389/fgene.2013.00061. eCollection 2013.
Abstract
MOST GENETIC EPIDEMIOLOGICAL STUDY DESIGNS FALL INTO ONE OF TWO CATEGORIES
family based and population-based (case-control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.
摘要
大多数遗传流行病学研究设计可归入两类之一
基于家庭的和基于人群的（病例对照）。然而，最近统计遗传学的进展要求将这两种方法结合起来的研究设计。我们描述了家庭接触研究设计，因为我们已经在几年的结核病流行病学研究中应用了这种设计。虽然我们强调了它在传染病遗传流行病学研究中的适用性，但这种设计的许多方面对于现代遗传研究都很有吸引力，包括同时招募相关和不相关的个体、密切和远缘个体、收集广泛的流行病学和表型数据，以及评估共享环境和基因与环境相互作用的影响。这些研究设计特点对于当前的测序研究特别有吸引力。
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