Babiker Ali Yousif, Eltom Faris Margani, Abdalaziz Mohamed S, Rahmani Arshad, Abusail Saadalnour, Ahmed Hussain Gadelkareem
Department of Histopathology and Cytology, College of Medical Laboratories Science, Sudan University for Sciences and Technology Sudan.
Int J Clin Exp Med. 2013 Apr 12;6(4):275-81. Print 2013.
HR-HPV subtypes are strongly linked to etiology of many human cancers including oral cancer. The epidemiology of infection with different HPV genotypes greatly varies in different countries. The aim of this study was to identify and genotype the HR-HPV subtypes in oral tissues obtained from Sudanese patients with oral lesions. In this retrospective study 200 patients with oral lesions were screened by molecular methods (PCR) for the presence of HR-HPV subtypes. Of the 200 patients, 100/200 were patients with oral cancer (ascertained as case group) and 100/200 were patients with non-neoplastic oral lesions (ascertained as control group). Out of the 200 patients, 12/200 (6%) were found with HR-HPV infection. Of the 12 positive patients, 8/12 (66.7%) were among cases and the remaining 4/12 (33.3%) were among control group. The distribution of different genotypes was: type HPV 16 6/12 (50%), HPV18 4/12 (34%), HPV 31 1/12 (8%) and HPV 33 1/12 (8%). In view of these findings, HPV particularly subtypes 16 and 18 play a role in the etiology of oral cancer in the Sudan.
高危型人乳头瘤病毒（HR-HPV）亚型与包括口腔癌在内的多种人类癌症的病因密切相关。不同HPV基因型的感染流行病学在不同国家差异很大。本研究的目的是鉴定苏丹口腔病变患者口腔组织中的HR-HPV亚型并进行基因分型。在这项回顾性研究中，采用分子方法（PCR）对200例口腔病变患者进行筛查，以检测HR-HPV亚型的存在。在这200例患者中，100例为口腔癌患者（确定为病例组），100例为非肿瘤性口腔病变患者（确定为对照组）。在200例患者中，发现12例（6%）感染了HR-HPV。在这12例阳性患者中，8例（66.7%）在病例组，其余4例（33.3%）在对照组。不同基因型的分布为：HPV 16型6例（50%），HPV18型4例（34%），HPV 31型1例（8%），HPV 33型1例（8%）。鉴于这些发现，HPV尤其是16型和18型在苏丹口腔癌的病因中起作用。
