Peng Juan, Yuan Yan, Shen Feng, Wang Yan, Chen Lichan, Liao D Joshua, Tan Yujie
Central Laboratory, Guizhou Medical University Hospital, Guiyang, Guizhou 550004, P. R. China.
Blood Transfusion Department, TaiHe Hospital Affiliated to HuBei University of Medicine, ShiYan, HuBei 442000, P. R. China.
J Cancer. 2017 May 11;8(7):1263-1270. doi: 10.7150/jca.17120. eCollection 2017.
The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36.98%. Most (72.08%) infectors were positive for only one HPV subtype, with the remaining being cases infected by two or more subtypes. Infections by the HPV subtypes 16, 52 and 58 were the most prevalent, having rates of 34.66%, 16.03%% and 15.53%, respectively. The most common cervical lesions in HPV infections were genital warts, cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). Age and age at first sexual activity were independent risk factors for HPV infections that in turn cause certain cervical lesions. Intriguingly, while 94.90% of the CC patients were infected by oncogenically high-risk (HR) HPV subtypes, only 2.75% and 2.29% of these patients were infected by oncogenically low-risk (LR) subtypes or other-subtypes with their oncogenicity unclear. The rates of infection by LR-HPVs and other-HPVs were also low, being 4.63% and 6.76%, respectively, in the patients with CIN that is a precursor lesion of CC, lower than the 8.54% and 18.20%, respectively, in the women without a cervical lesion. Our data provides an important foundation for prevention, diagnosis and treatment of HPV infection in Guiyang district and suggests that development of vaccines for prevention and treatment of CC in this area should first target the HPV subtypes 16, 52 and 58, but not subtype 18 as for many other places. It deserves study whether infections by certain LR-HPVs and other-HPVs may serve as attenuated live vaccines for prevention of CC.
不同基因型人乳头瘤病毒（HPV）的感染率在不同地理区域存在差异。我们研究了来自中国西南部以少数民族为主的贵阳市地区4213名女性宫颈组织标本中21种HPV基因型的感染率，我们队列中有2074例病例有病理诊断结果。总体感染率为36.98%。大多数感染者（72.08%）仅一种HPV亚型呈阳性，其余为感染两种或更多亚型的病例。HPV 16、52和58亚型感染最为普遍，感染率分别为34.66%、16.03%和15.53%。HPV感染中最常见的宫颈病变为尖锐湿疣、宫颈癌（CC）和宫颈上皮内瘤变（CIN）。年龄和首次性行为年龄是HPV感染继而导致某些宫颈病变的独立危险因素。有趣的是，虽然94.90%的CC患者感染了致癌性高危（HR）HPV亚型，但这些患者中仅2.75%和2.29%感染了致癌性低危（LR）亚型或致癌性不明的其他亚型。LR-HPV和其他HPV的感染率也较低，在CC的前驱病变CIN患者中分别为4.63%和6.76%，低于无宫颈病变女性中的8.54%和18.20%。我们的数据为贵阳市地区HPV感染的预防、诊断和治疗提供了重要依据，并表明该地区预防和治疗CC的疫苗研发应首先针对HPV 16、52和58亚型，而不像其他许多地方那样针对18亚型。某些LR-HPV和其他HPV的感染是否可作为预防CC的减毒活疫苗值得研究。
