Racine Jennifer, Aaron Roy K
Academic coordinator and research associate in the Department of Orthopaedics.
R I Med J (2013). 2013 Mar 1;96(3):19-22.
Osteoarthritis (OA) is a disease of high prevalence that produces substantial morbidity and is a leading cause of physical and psychological disability and expense, including time lost from work, medical care, and disability support. Until recently, the focus of research into the pathophysiology of OA has been on articular cartilage and has not resulted in either biomarkers of OA activity or effective targets for disease-modifying therapy. The contemporary paradigm of OA considers involvement of all joint tissues. It has been shown that, in later-stage OA, bone blood flow and oxygen content are markedly reduced and have a deleterious effect on bone cells, inducing them to release proteins (cytokines) that contribute to the bone remodeling and cartilage breakdown seen in OA.
骨关节炎（OA）是一种高发性疾病，会导致严重的发病率，是身体和心理残疾及费用的主要原因，包括工作时间损失、医疗护理和残疾支持费用。直到最近，对OA病理生理学的研究重点一直放在关节软骨上，但尚未产生OA活动的生物标志物或疾病修饰治疗的有效靶点。当代OA范式认为所有关节组织都会受累。研究表明，在晚期OA中，骨血流和氧含量会显著降低，并对骨细胞产生有害影响，促使它们释放有助于OA中骨重塑和软骨破坏的蛋白质（细胞因子）。
