钯催化的从异氰化物、重氮化合物和亚胺一锅合成多取代丙烯酰胺。
Pd-catalyzed one-pot synthesis of polysubstituted acrylamidines from isocyanides, diazo compounds, and imines.
机构信息
College of Chemistry and Chemical Engineering, Hunan Normal University , No. 36 Lushan Road, Changsha, Hunan, 410081, China, and Key State Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , No. 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530, China.
出版信息
Org Lett. 2013 May 17;15(10):2478-81. doi: 10.1021/ol4009552. Epub 2013 May 3.
A novel and efficient Pd-catalyzed one-pot reaction of ethyl diazoacetate, isocyanides, and imines for the synthesis of acrylamidines was developed. The multicomponent reaction may have occurred through an unpredicted ring-opening process of the ketenimine-imine [2 + 2] intermediate to form the acrylamidine products.
发展了一种新颖、高效的 Pd 催化的乙基重氮乙酸酯、异氰化物和亚胺一锅反应合成丙烯酰胺的方法。多组分反应可能通过酮亚胺-亚胺[2+2]中间体的意外开环过程发生，形成丙烯酰胺产物。
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