Gujarat Forensic Sciences University, Institute of Research & Development, DFS Headquarters, Sector 18-A, Gandhinagar, Gujarat-382007, India.
Expert Opin Investig Drugs. 2013 Jul;22(7):863-80. doi: 10.1517/13543784.2013.794783. Epub 2013 May 6.
Natural polyphenols, the non-essential micronutrients, found in array of plant products, are known to affect various physiological and biochemical functions in the body. Studies have shown the protective effect of these polyphenols in different neurological and mental disorders. These polyphenols modulate monoaminergic neurotransmission in the brain and thus possess antidepressant-like activity at least in animal models of depression.
The present review discusses the use of these natural polyphenols in the treatment of major depression. The review article discusses the antidepressant potential of some important polyphenols such as amentoflavone, apigenin, chlorogenic acid, curcumin, ferulic acid, hesperidin, rutin, quercetin, naringenin, resveratrol, ellagic acid, nobiletin and proanthocyanidins. The mechanism of action of these polyphenols in the treatment of major depression is also discussed in detail.
There is an exciting prospect in the discovery of natural polyphenols as therapeutic agents in the treatment of major depression.
天然多酚是植物产品中存在的非必需微量营养素，已知其可影响体内的各种生理和生化功能。研究表明，这些多酚在不同的神经和精神障碍中具有保护作用。这些多酚可调节大脑中单胺能神经递质的传递，因此至少在抑郁症的动物模型中具有抗抑郁样活性。
本综述讨论了这些天然多酚在治疗重度抑郁症中的应用。综述文章讨论了一些重要多酚如芹菜素、芹菜素、绿原酸、姜黄素、阿魏酸、橙皮苷、芦丁、槲皮素、柚皮苷、白藜芦醇、鞣花酸、川陈皮素和原花青素的抗抑郁潜力。还详细讨论了这些多酚在治疗重度抑郁症中的作用机制。
作为治疗重度抑郁症的治疗剂，天然多酚的发现前景令人兴奋。
