Bardinet Jeanne, Pouchieu Camille, Chuy Virginie, Merle Bénédicte, Pellay Hermine, Lefèvre-Arbogast Sophie, Helmer Catherine, Gaudout David, Samieri Cécilia, Delcourt Cécile, Cougnard-Grégoire Audrey, Féart Catherine
Univ. Bordeaux, INSERM, BPH, U1219, Bordeaux, F-33000, France.
Activ'Inside, Beychac-et-Caillau, 33750, France.
Eur J Nutr. 2025 Feb 11;64(2):88. doi: 10.1007/s00394-025-03597-x.
Nutrition, as a modifiable exposure, seems relevant to prevent depression. Several nutrients have been associated with a lower risk of depression in older adults, but longitudinal studies examining nutrient combinations are lacking. Therefore, we investigated the association between a posteriori nutrient patterns and the odds of depressive symptomatology (DS) in older adults over time.
The sample included participants from the French Three-City cohort, a prospective population-based study focusing on adults ≥ 65 years. Nutrient intakes were assessed using a 24-hour recall in 2001 and Principal Component Analysis based on 40 nutrients, was performed to identify nutrient patterns. DS was assessed at each visit (up to eight visits until 2018) and defined by a Center for Epidemiologic Studies-Depression score ≥ 16 and/or antidepressant medication. Random effect logistic regression was performed to examine the association between nutrient patterns and DS over time controlled for potential confounding variables.
The study sample comprised 1,063 individuals (mean age 75.6y +/- 4.8) and 39.3% experienced DS at least once during a median follow-up of 11.5 years. Among 4 identified nutrient patterns, the first pattern characterised by high intake of magnesium, hydroxybenzaldehydes, stilbenes, dihydroflavonols, vitamin B6, lignans, tyrosols, folates, vitamins B3, B5, B1 and proanthocyanidins, was significantly associated with lower odds of DS over time (OR + 1 point = 0.85, 95% CI=[0.75;0.96]).
In this large sample of older adults, a mixed nutrient pattern was associated with lower odds of DS over time, offering valuable insights into nutrient potential role in mental health among older adults.
营养作为一种可改变的影响因素，似乎与预防抑郁症相关。几种营养素已被证实与老年人患抑郁症风险较低有关，但缺乏对营养素组合进行纵向研究。因此，我们调查了事后营养素模式与老年人随时间出现抑郁症状（DS）几率之间的关联。
样本包括来自法国三城市队列研究的参与者，这是一项基于人群的前瞻性研究，重点关注65岁及以上成年人。2001年通过24小时膳食回顾法评估营养素摄入量，并基于40种营养素进行主成分分析以确定营养素模式。每次随访时评估DS（截至2018年最多随访8次），DS定义为流行病学研究中心抑郁量表评分≥16分和/或使用抗抑郁药物。采用随机效应逻辑回归分析，在控制潜在混杂变量的情况下，研究营养素模式与随时间变化的DS之间的关联。
研究样本包括1063名个体（平均年龄75.6岁±4.8岁），在11.5年的中位随访期内，39.3%的个体至少经历过一次DS。在确定的4种营养素模式中，第一种模式的特征是大量摄入镁、羟基苯甲醛、芪类、二氢黄酮醇、维生素B6、木脂素、酪醇、叶酸、维生素B3、B5、B1和原花青素，该模式与随时间推移DS几率较低显著相关（OR每增加1分 = 0.85，95%CI = [0.75;0.96]）。
在这个大型老年人群样本中，一种混合营养素模式与随时间推移DS几率较低相关，这为营养素在老年人心理健康中的潜在作用提供了有价值的见解。
