Young R P, Hart B J, Faux J A, Hopkin J M
Osler Chest Unit, Churchill Hospital, Oxford, U.K.
Clin Exp Allergy. 1990 May;20(3):319-25. doi: 10.1111/j.1365-2222.1990.tb02690.x.
Twenty-five atopic children under 11 years of age were studied, using skin and RAST tests, for their specific IgE response to four species of pyroglyphid house dust mites, Dermatophagoides pteronyssinus, D. farinae, D. microceras and Euroglyphus maynei. All of the children were sensitive to D. pteronyssinus, 20 (80%) of these children were also sensitive to D. farinae and D. microceras, and 16 of the latter (64%) were also sensitive to E. maynei. Dust samples from various sites in the homes of the children revealed D. pteronyssinus in all homes studied but no D. farinae or D. microceras. E. maynei, although identified, was not present in significant numbers in any site. A control group of 20 atopic children of similar age who were not sensitive to house dust mite allergens had a similar exposure to the four mite species. These results suggest that factors in addition to mite exposure are important in the development of specific IgE responses to house dust mites.
对25名11岁以下的特应性儿童进行了研究，通过皮肤试验和放射性变应原吸附试验（RAST），检测他们对四种粉尘螨（屋尘螨、粉尘螨、微角尘螨和梅氏嗜霉螨）的特异性IgE反应。所有儿童对屋尘螨均敏感，其中20名（80%）儿童对粉尘螨和微角尘螨也敏感，后两者中有16名（64%）对梅氏嗜霉螨也敏感。从这些儿童家中不同地点采集的灰尘样本显示，在所有研究的家庭中均发现了屋尘螨，但未发现粉尘螨或微角尘螨。虽然检测到了梅氏嗜霉螨，但在任何地点其数量均不显著。一组20名年龄相仿、对屋尘螨过敏原不敏感的特应性儿童作为对照组，他们接触这四种螨虫的情况相似。这些结果表明，除了接触螨虫外，其他因素在对屋尘螨特异性IgE反应的发展中也很重要。
