Ezzedini Rana, Darabi Maryam, Ghasemi Babollah, Darabi Masoud, Fayezi Shabnam, Jabbari Moghaddam Yalda, Mehdizadeh Amir, Abdollahi Shahin, Gharahdaghi Abasaad
Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):1008-12. doi: 10.1016/j.ijporl.2013.03.033. Epub 2013 May 2.
Tonsillar hypertrophy cells appear to have an altered lipid metabolism as evidenced by modulated inflammatory cytokines that affect tissue lipid metabolism. The aim of this study was to investigate differences in tissue fat composition between obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children.
Tonsillar tissues were collected from 114 patients with OSA and 92 patients with RT, aged 4-10 years, during tonsillectomy. The tissue lipid extracts were analyzed by gas liquid chromatography for a comprehensive fatty acid profile.
In the tonsillitis tissue, the levels of palmitoleic acid (16:1n-7; P=0.002) and oleic acid (18:1n-9; P=0.003) were higher, and the level of stearic acid (18:0; P=0.004) was lower than that in the hyperplastic tonsillar tissue. Overall, tonsillar tissue of patients with RT had a significant increase in the total monounsaturated fatty acids (+9.9%; P<0.001) and the fatty acid desaturation index (+20.5%; P<0.001). Furthermore, oleic acid content of tonsillar tissue was positively correlated with BMI (r=0.20, P=0.004), snoring (r=0.16, P=0.022) and hypertrophy grade (r=0.18, P=0.023), which remain significant in the subgroup analysis by hypertrophy type.
The change in the fatty acid composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human tonsillar hypertrophy, which might be linked to the severity or type of the tissue damage.
扁桃体肥大细胞似乎存在脂质代谢改变，这可由影响组织脂质代谢的炎性细胞因子的调节来证明。本研究的目的是调查儿童阻塞性睡眠呼吸暂停（OSA）和复发性感染性扁桃体炎（RT）之间组织脂肪成分的差异。
在扁桃体切除术中，收集了114例4至10岁的OSA患者和92例RT患者的扁桃体组织。通过气相色谱法分析组织脂质提取物，以获得全面的脂肪酸谱。
在扁桃体炎组织中，棕榈油酸（16:1n-7；P=0.002）和油酸（18:1n-9；P=0.003）的水平较高，而硬脂酸（18:0；P=0.004）的水平低于增生性扁桃体组织。总体而言，RT患者的扁桃体组织中总单不饱和脂肪酸显著增加（+9.9%；P<0.001），脂肪酸去饱和指数显著增加（+20.5%；P<0.001）。此外，扁桃体组织中的油酸含量与BMI（r=0.20，P=0.004）、打鼾（r=0.16，P=0.022）和肥大程度（r=0.18，P=0.023）呈正相关，在按肥大类型进行的亚组分析中这些相关性仍然显著。
脂肪酸组成的变化可被视为人类扁桃体肥大期间体内发生的脂质代谢改变的指标，这可能与组织损伤的严重程度或类型有关。
