Nat Cell Biol. 2013 Jun;15(6):572-5. doi: 10.1038/ncb2750. Epub 2013 May 5.
Although myelination largely occurs during early postnatal life, myelinating oligodendrocytes are still generated in the adult brain. Myelin turnover in the adult is necessary for proper neuronal function and is gravely compromised in myelin disorders. The lineage relationship between adult neural stem cells and adult-born oligodendrocytes has been clarified, highlighting molecular pathways that could potentially be targeted to favour de novo myelination in pathological situations.
尽管髓鞘形成主要发生在出生后的早期阶段，但在成年大脑中仍会产生髓鞘形成的少突胶质细胞。成年期的髓鞘更新对于神经元的正常功能是必需的，而在髓鞘疾病中则严重受损。成年神经干细胞和成年产生的少突胶质细胞之间的谱系关系已经得到阐明，这突显了潜在的分子途径，这些途径可能在病理情况下被靶向以促进新的髓鞘形成。
