Department of Psychiatry, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Eur Arch Psychiatry Clin Neurosci. 2014 Feb;264(1):83-7. doi: 10.1007/s00406-013-0411-6. Epub 2013 May 5.
Several researches indicate that autonomic nervous system (ANS) dysfunction in patients with schizophrenia. Recently, salivary alpha-amylase (sAA) has been employed as a useful marker for ANS function. We investigated the extent of ANS dysfunction by measuring sAA and heart rate variability (HRV) of 25 patients with schizophrenia compared with controls. Schizophrenia group demonstrated a significant increase in sAA and markedly lower parasympathetic nervous system (PNS) activity in the HRV. However, there were no significant differences between two groups in sympathetic nervous system (SNS) activity. We concluded that PNS might be suppressed and the SNS shows relatively high activity in schizophrenia.
几项研究表明，精神分裂症患者的自主神经系统（ANS）功能障碍。最近，唾液α-淀粉酶（sAA）已被用作 ANS 功能的有用标志物。我们通过测量 25 名精神分裂症患者和对照组的 sAA 和心率变异性（HRV）来研究 ANS 功能障碍的程度。精神分裂症组的 sAA 显著增加，HRV 中的副交感神经系统（PNS）活动明显降低。然而，两组之间的交感神经系统（SNS）活动没有显著差异。我们得出结论，精神分裂症中 PNS 可能受到抑制，而 SNS 表现出相对较高的活性。
