Crume Tessa L, Andrews Jeanette S, D'Agostino Ralph B, Pettitt David J, Mayer-Davis Elizabeth J, Law Jennifer R, Dolan Lawrence, Lawrence Jean M, Saydah Sharon, Greenbaum Carla, Rodriguez Beatriz L, Dabelea Dana
J Pediatr Endocrinol Metab. 2013;26(7-8):721-7. doi: 10.1515/jpem-2012-0385.
Abstract We explored the influence of exposure to maternal diabetes in utero on β cell decline measured by fasting C-peptide (FCP) among 1079 youth <20 years with diabetes, including 941 with type 1 and 138 with type 2 diabetes. Youths exposed to maternal diabetes had FCP levels that were 17% lower among youth with type 2 diabetes [95% confidence interval (CI): -34%, +6%] and 15% higher among youth with type 1 diabetes (95%CI: -14%, +55%) than their unexposed counterparts, although differences were not statistically significant (p=0.13 and p=0.35, respectively). Exposure to maternal diabetes was not associated with FCP decline in youth with type 2 (p=0.16) or type 1 diabetes (p=0.90); nor was the effect of in utero exposure on FCP modified by diabetes type. Findings suggest that exposure to maternal diabetes in utero may not be an important determinant of short-term β-cell function decline in youth with type 1 or type 2 diabetes.
摘要 我们在1079名20岁以下的糖尿病青年中探讨了子宫内暴露于母亲糖尿病对通过空腹C肽（FCP）测量的β细胞衰退的影响，其中包括941名1型糖尿病患者和138名2型糖尿病患者。与未暴露于母亲糖尿病的同龄人相比，暴露于母亲糖尿病的2型糖尿病青年的FCP水平低17%[95%置信区间（CI）：-34%，+6%]，1型糖尿病青年的FCP水平高15%（95%CI：-14%，+55%），尽管差异无统计学意义（p分别为0.13和0.35）。暴露于母亲糖尿病与2型（p=0.16）或1型糖尿病（p=0.90）青年的FCP衰退无关；子宫内暴露对FCP的影响也不受糖尿病类型的影响。研究结果表明，子宫内暴露于母亲糖尿病可能不是1型或2型糖尿病青年短期β细胞功能衰退的重要决定因素。
