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对一家三级护理中心的 200 例中枢神经系统肿瘤及其手术治疗进行回顾性审计。

A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre.

机构信息

Department of Neurosurgery, Cork University Hospital, Wilton, Cork, Republic of Ireland,

出版信息

Ir J Med Sci. 2013 Dec;182(4):697-701. doi: 10.1007/s11845-013-0959-1. Epub 2013 May 4.

Abstract

AIMS

To study the nature of the tumours managed in the Irish population.

METHODS

This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.

RESULTS

The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.

CONCLUSIONS

Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

摘要

目的

研究在爱尔兰人群中治疗的肿瘤的性质。

方法

这项审计研究通过对 200 名在 2008 年至 2009 年期间在三级护理中心治疗的中枢神经系统肿瘤患者进行回顾性医学审查来完成。

结果

平均年龄为 53 岁。男女比例为 2:1。大多数为胶质母细胞瘤和星形细胞瘤。IV 级肿瘤占主导地位(65.5%)。头痛(37%)、运动无力(32%)和癫痫发作(25.5%)是最高的表现。最常受影响的部位是左侧顶叶和左侧颞叶。手术并发症发生率为 17.5%,运动无力(22.9%)、癫痫发作(14.3%)和血栓栓塞(14.3%)占主导地位,与手术根治性有显著关联(p=0.041)。报告了 3.5%的手术死亡率。分别有 52.5%和 62.5%的患者接受了辅助化疗和放疗。

结论

患有中枢神经系统肿瘤的患者通常有多种表现。更广泛的手术切除与更高的术后发病率相关(p=0.041)。30 天术后发病率(17.5%)和死亡率(3.5%)与目前可用的文献一致。

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